00:00:00 – JJ Virgin
Collagen is one of the most talked about supplements on the planet and the reality is most people are using it wrong. Now, if you’re over 30 and taking collagen, hoping that’s going to magically fix those wrinkles, your joints and your bone health, you need to hear this. Hey, I’m J.J. virgin, Ph.D. dropout. Sorry mom. Turned four time New York Times bestselling authority as a certified Nutrition Specialist, Fitness hall of Famer, and globally recognized leader in health. I’m driven to keep asking the tough questions and use my podcast to simplify the science of health into actionable strategies that help you thrive.

00:00:43 – JJ Virgin
I’d also love to hear your thoughts on the show. And here’s the fun part. When you send me your review, I’ll reply to you using my on demand virtual Me. That’s right, my team and I created a virtual JJ packed with my books but speeches and wisdom so I can personally connect with you. Here’s how you do it. Subscribe and leave an honest review of the podcast. Take a screenshot of your review, text it to 813-565-2627. That’s 813-565-2627. My virtual JJ will reply directly and trust me, this will make your day. So subscribe now@subscribetoj.com and text me your review. Let’s keep thriving together. Have you ever wondered whether collagen actually works or if it’s just an expensive and incomplete protein powder? Hey, I’m JJ Virgin, four time New York Times bestselling author and nutrition expert and I’ve been studying connective tissue, muscle and aging physiology for for decades.

00:01:51 – JJ Virgin
And I’m going to break down what collagen actually does, which the research actually shows, and exactly how to use it for skin, joints and bone without falling for all the hype. Because collagen isn’t magic, but when used correctly it can be powerful. And spoiler alert, it is something I take every single day. So what about you who should take collagen? Well, collagen makes sense for you if you are 30 plus if you’re lifting weights and if you’re not, get on it.

00:02:23 – JJ Virgin
If you’ve got any kind of joint discomfort and joint pain, if you’re perimenopausal or postmenopausal, if you want to support and better skin elasticity, if you care about your bone health, then this is something you’re going to want to look at. This doesn’t make sense. If you are using it as a high quality protein source you’re going to learn why it is not. Or if you are under eating total protein and you think this is going to save you, because here’s the reality. Collagen. Think of it as a support supplement. Again, as I said before, collagen is not a miracle. It’s a support supplement. And it best works when it’s layered in with other things as part of your muscle first strategy.

00:03:09 – JJ Virgin
All right, so let’s talk about what collagen has actually is. Collagen is the most abundant protein in your body. It actually makes up about 30% of your total protein mass. It forms a structure for your skin, for your tendons, for your ligaments, for your cartilage, for your bone. So, yeah, it’s that important. Now I said, who’s it for? And one of the things I said was, if you’re 30 plus.

00:03:33 – JJ Virgin
Why? Because after age 30, collagen production starts to naturally decline about 1% per year. And then in women, this thing, of course, like everything, seems to accelerate during perimenopause and menopause. Why? Because estrogen plays a major role in collagen synthesis. There was a study published in the Dermatoendocrinology Journal that showed that estrogen deficiency significantly reduces collagen content in skin. And of course, what’s that mean? Estrogen plays a major role in maintaining skin structure and function. Now, after menopause, estrogen deficiency accelerates all that visible skin aging. So that’s why you’ve seen a lot of us be included using estradiol skin creams, because lower estrogen levels lead to thinner skin, and a lot of that’s due to reduced collagen content. So what is estrogen doing? Well, estrogen influences your fibroblasts. Your fibroblasts are the cells that are responsible for producing collagen. And this declining estrogen is associated as well with decreased skin elasticity and increased wrinkling. So this is why skin elasticity drops and joints feel stiffer and recovery just takes longer as we age. It’s not vanity, it’s not cosmetic. It’s actually structural aging. Sorry about that. So here’s the big thing, though, and the big myth, because you’ll hear collagen, it’s a protein, but it’s not a complete protein.

00:05:10 – JJ Virgin
And this is where people mess everything up. So collagen’s not a complete protein because it’s actually missing completely the essential amino acid tryptophan. But it’s also low in other essential amino acids, especially the super duper important one for muscle Leucine, because leucine, this is Dr. Donald Layman’s work, is shown to be the primary trigger for muscle protein synthesis research. Research published in Frontiers of Nutrition showed that leucine is the key amino acid that activates the MTOR pathway to trigger muscle protein synthesis. And collagen doesn’t provide enough leucine to do that. So if you’re replacing your whey protein or your whole food protein with collagen, thinking I got what I need to build muscle, you don’t. I love the whey protein or the other protein with collagen, but don’t kick collagen on its own. Collagen’s there to support connective tissue. We whey, eggs, meat, fish, my plant based protein powder, my paleo inspired protein powder. Those can build muscle, but they’re not interchangeable. Okay, super important. Now what about skin? Does collagen improve your skin? And let’s talk about wrinkles. There have been now multiple randomized control studies looking at collagen peptides in skin health.

00:06:24 – JJ Virgin
I’m going to talk about one that was published in the Journal of Drugs and Dermatology that found that oral collagen supplementation improves skin elasticity, skin hyd in dermal collagen density when compared to placebo. And this review, this was cool because it was looking at 11 other randomized placebo controlled human trials of oral collagen supplementation and a total of over 800 participants across all of these different trials. And what they came to the conclusion of was that oral collagen supplementation was associated with improvements in skin elasticity as compared to placebo. Several of the studies reported increased skin hydration following the collagen supplementation. And some of the trials showed increased dermal collagen density with collagen supplementation. And they dosed anywhere from 2 1/2 grams to 10 grams per day. The intervention periods were anywhere from a month to two years.

00:07:23 – JJ Virgin
Wild that they would do a study for that long. But I guess it’s not like doing an exercise study where it’s hard to get compliance. Here’s the thing, with collagen, it’s totally safe. There’s not going to be an issue with it. There’s no adverse events from it. It’s just a matter of spending the money on it. Now there was another study that came out in 2021.

00:07:41 – JJ Virgin
This was another meta analysis in the International Journal of Dermatology. And what they found was that hydrolyzed collagen significantly improved skin elasticity and reduced wrinkles after just eight to 12 weeks. Now, this was a 2021 systematic review and meta analysis and it was published in the of Dermatology. And it looked at 19 randomized double blind controlled trials with over a thousand participants from aging anywhere from 20 to 70 years old. 95% of these people were women. Not sure why they would look at 20 year olds. I mean, come on. Anyhow, this meta analysis found statistically significant improvements in skin elasticity as compared to a placebo. And it also found significant reductions in wrinkles, improvements in hydration. And again, these trials were anywhere from a couple of weeks to 90 days.

00:08:36 – JJ Virgin
And they found that. And this is what the authors concluded, that the ingestion of hydrolyzed collagen reduced wrinkles and improved skin elasticity and hydration. So what do you get from all this, from all these different randomized control studies and comparison trials? Collagen improves your skin. But here’s where I think people get confused and misunderstand it. It is not like you take collagen and goes traveling to, oh, there’s your wrinkles, and goes and fills it in.

00:09:00 – JJ Virgin
It’s not like internal filler. You eat collagen, you take it, it digests into amino acids and small bioactive peptides, which are these tiny protein fragments that can act like signals. And what these researchers think is happening here is that these peptides are acting as signaling molecules that stimulate these fibroblasts, and those are those cells that are responsible for producing collagen in your skin. So when you think about it, these signals are a stimulus. So I want you to think of collagen as a signal, as a stimulus, not as like, you know, ingestible filler. Okay. Which is tempting to do, right? So I think very exciting for skin. That was initially, I will say, full disclosure as to why I was so excited about it, but I will tell you why I’m even more excited about it.

00:09:49 – JJ Virgin
And it is for the joint side of things. And if you know me at all, you know I was a really dumb young athlete and I have a lot of joint kryptonite because of that. So joints. I think this is where collagen really shines in. Current medical research and opinion that showed that athletes supplementing with collagen hydrolysate experienced significantly reduced joint pain compared to placebo.

00:10:11 – JJ Virgin
And again, this was a randomized, double blind, placebo controlled trial. Those are like the gold standard trials had 147 athletes that enrolled 97 included in the final statistical analysis of this. And what they found with it was that oh, and again, these people were physically active athletes and they had activity related joint pain, no joint disease. So it wasn’t people with osteoarthritis, that type of stuff. It was just like people who were doing athletic stuff and their joints ached. And what they found was the collagen group experienced statistically significant reductions in joint pain compared to the people with the placebo. They took 10 grams a day. They did it for 24 weeks. And the pain reduction was observed both at rest and during movement, during walking, during standing, during lifting, carrying objects. And again, it was especially pronounced. This is important to me with my knee issues in those athletes with knee pain.

00:11:09 – JJ Virgin
So that is a very exciting one. And then there was another one. Okay, so this is a study in the American Journal of Clinical Nutrition that showed that taking a collagen derived protein with vitamin C before exercise increased markers of collagen synthesis linked to tendon and ligament remodeling. And again, another randomized double blind placebo controlled crossover trial where they had in very small subject group, eight healthy male participants, and they used 5 grams or 15 grams of a vitamin C enriched gelatin, or they used a placebo and they took it an hour before they did exercise.

00:11:44 – JJ Virgin
They did jumping exercises. And what they found was an increase in the circulating amino acids that were used for collagen formation. The 15 gram dose doubled a blood marker of collagen synthesis versus the placebo. And the findings suggested that a pairing a collagen derived protein and vitamin C with exercise supports tendon and ligament remodeling. Now, this is important because why vitamin C. Vitamin C is required to help your body turn those collagen building blocks into strong, stable collagen. And one of the things that we know with collagen, when you add in mechanical loading, meaning you do some type of resistance training, it helps increase connective tissue remodeling. So if you’re lifting weights and you’re taking collagen with vitamin C, you may improve tendon strength and resilience. And that matters as we age, because, man, it’s when you look at what happens as we start to lift weights as we’re older, the injuries are not happening in the muscle.

00:12:43 – JJ Virgin
They’re happening where the muscle and the tendon connect or the tendon and the bone connect. It’s the connective tissue that’s the issue. I didn’t even mean to rhyme, and I did. And this is why I take my collagen plus vitamin C before I work out. Next up is let’s talk bones and aging. And remember, bone is not just calcium. Bone is a collagen matrix that gets mineralized with calcium.

00:13:06 – JJ Virgin
So there was a randomized controlled trial published in 2018 in Nutrients that showed the postmenopausal women who supplemented with Collagen peptides for 12 months had significant improvements in bone marrow density compared to placebo. Man, is that super duper important. Think about that. Because part of what happens after menopause is bone mineral density falls off a cliff. We can lose 2 to 5% a year. For the first couple years, this was 131 women who were enrolled. And again, it was 12 months where they got either the specific collagen peptides or they got a placebo. And what they discovered here was that the collagen group experienced significant increases in bone marrow density at the spine and hip compared to placebo. That is huge. The bone formation markers increased in the collagen group, while markers of bone breakdown increased in the placebo group. And so the authors concluded that specific collagen peptides improve bone marrow density and support bone formation in perimenopausal women. I mean, this is a super duper big deal, because in menopause, remember, estrogen’s going down, progesterone’s going down, testosterone’s going down, and bone loss is accelerating. So if you want strong bones, you gotta load them. You’ve gotta have good vitamin D. You gotta make sure you’re taking in protein, but then collagen too, especially after 40.

00:14:26 – JJ Virgin
And a very specific form of collagen that’s been studied here, something called fortagel. I created a collagen that has varisol, which is the one studied for skin fortigel. What’s studied for bone? Vitamin C to help with making your collagen. And I have been taking 10 grams now before I go and work out when I have more blood flow to the joints. So that’s my little secret sauce. And a lot of times if I’m fasting, I’ll just throw that into my coffee.

00:14:50 – JJ Virgin
It just dissolves. It’s easy. And if not, you know, then I throw it into my smoothie or into my yogurt. So I just use my Reignite Wellness collagen peptides. Like that. Easy peasy. Now, if you’ve been following me for any amount of time, you know that muscle is the priority. Muscle drives your metabolism, muscle protects your bone. Muscle determines how you age and can make sure that you age powerfully. And collagen here again is a support nutrient. It’s not magic. It’s a great support nutrient though.

00:15:20 – JJ Virgin
Get the fundamentals right. Build your muscle, eat your protein, challenge your muscles and then use collagen strategically for that connective tissue support and that skin support and that bone support. Now if you want more straight science back breakdowns without the fluff hit subscribe. I’m here every week cutting through the noise so that you can train smarter and age more powerfully. Because understanding how your body actually works changes everything. Be sure to join me next time for more tools, tips and techniques you can use to learn, look and feel your best and be built to last. Also, I’d love to connect with you and hear your thoughts on the podcast. Here’s how. First, subscribe to the podcast and leave an honest review.

00:16:08 – JJ Virgin
Second, take a screenshot of your review and third, text it to 813-565-2627. That’s 813-565-2627. When you do, I’ll reply using my brand new virtual jj. It’s my on demand virtual self built from my books, talks and years of experience so I can interact with you directly. You’ll make my day and I can’t wait to hear from you. Thanks for tuning in and I’ll catch you on the next episode. Hey Jeja here. And just a reminder that the well Beyond 40 podcast offers health, wellness, fitness and nutritional information that’s designed for educational and entertainment purposes only.

00:16:56 – JJ Virgin
You should not rely on this information as a substitute for, nor does it replace professional medical advice, diagnosis or treatment. If you have any concerns or questions about your health, you should always consult with a physician or other healthcare professional. Make sure that you do not disregard, avoid or delay obtaining medical or health related advice from your healthcare professional because of something you may have heard on the show or read in our show notes. The use of any information provided on the show is solely at your own risk. It.

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