JJ Virgin
New research is making headlines. Olive Oil yes, our beloved EVOO could actually make you create new fat cells. So does that mean that you should toss your extra virgin olive oil and ditch the Mediterranean diet? Well, not so fast. I’m going to break down what the study really found, what this means for your health, and how to use olive oil in the smart way. And spoiler alert, while hyperplasia may sound like a bad thing, just wait till the end. There’s a plot. WB hey, I’m JJ Virgin, PhD dropout. Sorry mom. Turned four time New York Times Best selling author. As a certified Nutrition specialist, Fitness hall of Famer and globally recognized leader in health, I’m driven to keep asking the tough questions and use my podcast to simplify the science of health into actionable strategies that help you thrive.

00:55
JJ Virgin
I’d also love to hear your thoughts on the show. And here’s the fun part. When you send me your review, I’ll reply to you using my on demand virtual Me. That’s right, my team and I created a virtual JJ packed with my books, speeches and wisdom so I can personally connect with you. Here’s how you do it. Subscribe and leave an honest review of the podcast. Take a screenshot of your review. Text it to 813-565-2627. That’s 813-565-2627. My virtual JJ will reply directly and trust me, this will make your day. So subscribe now@subscribetoj.com and text me your review. Let’s keep thriving together. Let’s talk first about hypertrophy versus hyperplasia and I’m gonna break down the study, which exposes the dark side of too much evoo because it causes both the increase in size and number of fat cells.

02:00
JJ Virgin
So this was in 2025 published in Cell Reports study done by Yale and it found that the fatty acid composition of oils influences whether fat cells simply grow hypertrophy, get bigger or multiply hyperplasia, create more of them. Oleic acid was the only fatty acid tested that could drive new fat cell creation at fat physiological levels. The study found that this occurred when diets were designed with about a 45% total caloric load from fat with oleic acid as the main fat source. And the reason they did it this way is they were going to reproduce the high fat, high oleic load diet that you see in the ultra processed Western diet, not of course the Mediterranean diet. So we’re not talking a drizzle of authentic EVOO on a salad.

02:46
JJ Virgin
This study was modeling the kind of fat you’d get from a western diet that’s like 70% processed foods with a load of different OA rich seed oils stacked together. So what they did was they conducted an unbiased dietary screen in mice and they tested multiple fats. Coconut oil, peanut oil, lard, soybean oil. And again they found oleic acid was the only dietary fat that caused significant adipocyte precursor cell proliferation, leading to more fat cells. The oils that were found to be problematic were soybean oil, sunflower oil, safflower oil and peanut oil. And by the way, soybean oil is the number one oil that we eat here in the United States.

03:25
JJ Virgin
They cited olive oil in the study, but it really was these other oils that were used to mimic that 45% of fat in the standard American diet due the high intake again of ultra processed foods. And they also shared their concerns for high oleic canola and soybean oils. So why is OA an issue? Well, most of the time, fat gain happens by increasing the size of existing fat cells. OA can also make your body create brand new fat cells. The study showed that oleic acid acts like a signaling molecule. It triggers the growth switch akt2 that tells fat cells to multiply and releases the break LXR alpha that normally keeps fat cell growth under control. Okay, you got the gas pressed and the break off and your body ends up making new fat cells which can make fat loss more chall.

04:12
JJ Virgin
Now this was no small study. It was led by Dr. Rodeheffer’s hope I got that right. Yale’s lab with NIH funding and published in Cell reports which is of course a top peer reviewed journal. It’s highly credible. Now it’s still early days in pre clinical research, but it lines up with the UK Biobank data showing higher blood oleic acid linked to greater obesity risk. So the oils they used, again these were heavily processed, but the common thread throughout high OA content. And EVOO is high in oleic acid. So what’s that mean? Is it off the menu? Here’s the yes, EVOO is high in oleic acid, but so are other common canola. Sunflower, safflower oil are major sources of oleic acid, especially giveaway when the label says high oleic.

05:00
JJ Virgin
These seed oils often show up in all these different processed foods and dressings and of course restaurant meals because they’re cheap. If it says hyalic on the label, guess what it is. It’s high oleic like EVOO is. But without all the good stuff that evoo has, because evo has all these other things, which I’ll talk to you about in a bit. So reality is, the issue isn’t olive oil. It’s piling multiple OA rich, ultra processed oils on top of each other with a bunch of starchy processed carbs. We were meant to eat a variety of clean, minimally processed fats to achieve a balance of Mono Polyunsat and three 6 9s. Driving any one of these too high can lead to problems, but especially with these oas, Oleic acid excess is mainly a problem, though, in caloric surplus and a sedentary lifestyle.

05:51
JJ Virgin
So, overeat, don’t move, you got a problem. I mean, on my last trip to Italy, I felt like I was kind of drinking evol. I was pouring so much on my rocket salad and dredging my bread through it, and I wasn’t worried. Why? Because I was walking my butt off everywhere and I was not in a caloric surplus. The Mediterranean diet includes evo somewhere like 2 to 4 tablespoons a day in moderation. And of course, the Mediterranean diet isn’t just about olive oil. It has whole unprocessed foods that are rich in fiber, polyphenols, omega 3s, and a whole bunch of plant diversity. And what it doesn’t have are things like canola oil and sunflower oil and soybean oil and safflower oil. And unlike other high OA oils, extra virgin olive oil is unique. It doesn’t just deliver oleic acid.

06:36
JJ Virgin
It’s also packed with some amazing polyphenols along with antioxidants and vitamin E. And altogether, these compounds support heart health. They calm inflammation, and they protect your cells. In fact, olive oil is one of the most studied fats for cardiovascular health. Randomized clinical trials, large cohort studies, and meta analysis all support its role in lowering cardiovascular disease, improving lipid profiles, and reducing mortality. There was a study in the New England Journal of Medicine that found that a Mediterranean diet rich in extra virgin olive oil lowered the risk major heart events by about 30%. Now, in this study, participants had about four tablespoons of EVOO per day. That’s about 20 to 25% of their calories in a 2,000 calorie diet. And a review in nutrients showed that EVOO polyphenols can reduce inflammation and oxidative damage.

07:29
JJ Virgin
And all you needed there was like one to two tablespoons per day. Here’s my take on how to get the benefits of extra virgin olive oil without those hyalic downsides. First of all, get rid of the crappy oils again. In the United States, like our number one consumed oil is soybean oil. And so we’ve got canola, sunflower, safflower, soybean, grapeseed, rice bran. So lose those and especially the ones that are industrial processed. Instead swap them out for really high quality extra virgin olive oil. Now here’s a big cautionary tale. There’s a lot of posers out there. Ask the restaurant, oh, is this olive oil? They go, oh, it’s a blend. A blend means we cut your fabulous extra virgin olive oil with some cheap canola oil. And it’s mainly canola. And that is what you don’t want to do.

08:17
JJ Virgin
You also don’t want to just only do extra virgin olive oil. You want a mix of healthy fats. You want to be getting some omega 3s from Wild Salmon. You want to get some medium chain triglycerides from coconut. You want to get some monounsats from avocado. So get a whole bunch of different types because your body needs the balance. And a especially whenever you can go food first again, nuts, seeds, grass fed beef, wild fish. Right. And then the saturated that you go for, I go for ghee, I go for coconut, grass fed butter. By the way, none of those triggered fat cell hyperplasia in the cell report study. My favorite monounsaturated are avocado and olive. And then the polyunsats 3s and 6. These are things that we have to have. These are essential fatty acids.

09:01
JJ Virgin
My favorite omega 3s of course, wild fish, salmon. I wish I loved sardines. If you do a plus for you’re gon grass fed beef, a little bit in your flax, your hemp, your chia, those are good too. And then Omega 6, those are things like nuts and seeds. And again, we’re going to make sure we balance there because in the western diet where we tend to go high oleic acid processed, we get a little overload of that. And then of course a shout out to the medium chain triglycerides that are in coconut oil and your MCT oils because these are an easy fat to burn that are great for your brain. So olive oil. Yeah. If you’re doing too much of it and you’re eating too much food and you’re sitting on your butt and you’re eating processed foods, you’re. It can be problematic.

09:39
JJ Virgin
We got to do it in balance. But I’m not worried about that. If you’re eating it in a moderate amount. And you’re eating high quality, consuming high quality olive oil. I personally, for the last 10 years, I’ve been getting my olive oil from this company called Fresh Pressed Olive Oil Club. And there’s this guy, T.J. he’s known as the olive oil hunter. And he literally goes around the world getting the best sourced small farm olive oil. And it’s fabulous. I like to put it in a spritzer where I can spray my vegetables to roast up my vegetables. Incredible. And I use it to make my dressings. By the way, this study does not invalidate the Mediterranean diet at all. Keep all those plants, keep the fish, keep the fiber, get rid of the seed oils, especially the industrialized one.

10:23
JJ Virgin
Use the extra virgin olive oil, especially the high quality stuff like that stuff I just talked to you about from Fresh Pressed Olive Oil Club. Right. And of course, prioritize metabolic health by doing your resistance training, by moving a bunch, by eating protein first, getting good sleep, all the important things. Olive oil is not the villain here. Right. So super important. Now, I told you I had a spoiler alert and I do want to share that because this sounds like it’s really bad to have more fat cells. And at first blush you would go, oh, my gosh, I don’t want to build more fat cells. But I’m going to throw a curve ball at you to consider and I’m going to do a shout out to Dr. Ben Bickman, who is an amazing scientist out in Utah who studies insulin and mitochondria.

11:06
JJ Virgin
And here’s the thing, the actual danger isn’t having more fat cells. When you look at people’s metabolic health, it’s not problematic when you have more fat cells. It’s problematic when your fat cells get too full. That’s actually the issue. One of the issues with visceral adipose tissue, and if you’ve been listening to anything on my channel, you know, I’m always railing on visceral adipose tissue and telling you I want you to do a really good waist measurement weekly. A waist to hip and a waist to height, because that’s how we can monitor that you’re losing that visceral adipose tissue, that’s that fat around your organs. The reason that fat’s problematic is because it’s in a very small contained space. So your body’s not going to be able to make more fat cells there. There’s no room.

11:46
JJ Virgin
So instead they get swollen and when they get too big, they spill out. And that’s where you start to get problems. So when you have fat cells that are not over full. It’s actually not problematic. So if you have more fat cells, it’s not a bad thing. It can be hard when you’re trying to lose weight. But this studies show that when people have liposuction, their metabolic health doesn’t improve because now they have less fat cells. And if they go back to their old ways and those fat cells they have get swollen up now, they have worse metabolic health. So I just want you to consider that because I think we tend to think, oh, more fat cells bad. But it’s not that simple of a statement. It is more nuanced. And I think the biggest takeaway here is eat a balanced of oils.

12:27
JJ Virgin
Eat high quality oils. I always say you are what you eat to ate. It is really important in your fats because we store toxins in our fat and dietary fats can have toxins in them too. Toxins tend to love fat. So get clean fats, get them as close to nature as possible. If you’re getting oils first pressed, make sure they’re organic and make sure that you’re getting them in small dark bottles so they stay clean. And again, eat a balance of different fats. I do my grass fed ghee and I get it in glass. I do my olive oil from fresh pressed olive oil club and I get small dark bottles of that. I use a little sesame oil sometimes when I’m cooking organic small bottles. I might a little bit of avocado oil.

13:08
JJ Virgin
Usually I’ll do Primal kitchens dressings if I’m not making my own. But generally I make my own and I might use a little coconut oil or MCT oil and it’s that simple. Doesn’t have to be complicated. So that is the easy way to think about all of this. Don’t let the headlines freak you out. As the real takeaway, I love that the headlines all over were like olive oil is making you fat. It’s like that’s not even. The study didn’t even look at olive oil. It was looking at oleic acid from processed oils that have been processed in a way to drive up the oleic acid. So caution with what you’re reading because WB loves to make these inflammatory headlines. So as you can see, olive oil isn’t the villain. It’s still one of the healthiest fats you can have.

13:48
JJ Virgin
And again, the problem is too much oleic acid from all these other sources and then eating too much food and not moving enough. So we’re going to eat high quality extra virgin olive oil. We’re going to have other healthy fats from different sources like nuts, seeds, avocados, wild fish, and then keep moving. That way you’re going to get all the benefits of all these healthy fats without creating extra fat cells that you don’t want. And if you want more info on this, check out this podcast episode on the Truth About Seed Oils and learn if they’re really sabotaging your health. Be sure to join me next time for more tools, tips and techniques you can use to look and feel your best and be built to last. Also, I’d love to connect with you and hear your thoughts on the podcast. Here’s how.

14:37
JJ Virgin
First, subscribe to the podcast and leave an honest review. Second, take a screenshot of your review and third, text to 281-356-52627. That’s 813-565-2627. When you do, I’ll reply using my brand new virtual JJ. It’s my on demand virtual self built from my books, talks and years of experience so I can interact with you directly. You’ll make my day and I can’t wait to hear from you. Thanks for tuning in and I’ll catch you on the next episode. Hey JJ here. And just a reminder that the well Beyond 40 podcast offers health, wellness, fitness and nutritional information that’s designed for educational and entertainment purposes only. You should not rely on this information as a substitute for, nor does it replace professional medical advice, diagnosis or treatment.

15:35
JJ Virgin
If you have any concerns or questions about your health, you should always consult with a physician or other healthcare professional. Make sure that you do not disregard, avoid or delay obtaining medical or health related advice from your healthcare professional because of something you may have heard on the show or read in our show notes. The use of any information provided on the show is solely at your own risk.

Hide Transcript